We thought it might be useful to give you an example of how you, as a "Maker" who wants to get something made, would work with the "Fabber" who does the digital fabrication. Although the process will be unique for every project and program that you use, here are the steps I used to design the first set of LinkerLogs, and some fabrication-related issues that had to be considered. Even if your project is completely different than this, you may find the described steps helpful.
The LinkerLogs project evolved from an email from a friend, with a link to an article from a 1953 Mechanics Illustrated about a set of plywood building planks that were made using a traditional method ... a table saw. They seemed to be perfect for digital fabrication, which brought some modifications to mind:

A couple of decisions had to be made about critical dimensions and it was important to make them early on. I knew I wanted the logs to be cut out of 1/2" plywood, but plywood and other sheet goods are almost NEVER the size and thickness they are supposed to be and I knew that the plywood that they would be cut out of averaged between 0.46-0.47" thick. If material thickness is important to your project, a quick email to the Fabber that you've selected will let you know the exact thickness of the plywood that they would be cutting. I didn't want the fit to be too tight for little kids to assemble and disassemble, or so loose that it was floppy, so I decided on 0.48" wide slots.
Unlike the fit of the slots, the rest of the measurement decisions can be somewhat arbitrary and be based on aesthetics, material usage, and things like ease of handling for the end user. Although the Fabber would be cutting the parts out of a standard 96"x48" sheet of material, I also wanted to be able to cut them out of 24"x48" blanks on a PRSBuddy tool. So a maximum piece size of 4"x48" seemed about right. Since we would have to leave room for the width of cut, I decided on 3.5" wide planks, and this plank width dictated the depth of the slots, which had to be 1/4 of the width of the plank or .875". And 6" between slots seemed about right, with a 2" overhang on the ends. The design decisions were complete.
(click for full view of image)
The next step was to decide on sizes that would work well with standard plywood sheet sizes, based on the number of slots. An 8-slot piece ended up being about 46.5" long which would work nicely in both 4'x8' sheet material and 2'x4' blanks for the Buddy 48 tools and not be too big for small kids to handle, so that became the longest piece. 6-slot, 4-slot, 2-slot, and 1-slot pieces filled out the set.
Fortunately I only had to draw one pair of slots, then used the "linear copy" tool with 6" between the copies to make as many pairs of slots as I needed for each particular size of plank. Lines were drawn connecting each set of slots using the "End Snap" tool, and ends were added with rounded "Filleted" corners to make them safer and easier to handle.
(click for full view of parts)
The final step was to lay out the parts on a 4x8 sheet of material, leaving enough room for the cutting bit between pieces and around the sheet template. Once again the quantity of each size piece was arbitrary..good enough for a first version.
(click for full view of layout)
All that was left to do was to send my file to the Fabber and give them any special instructions. Here are some of the things I had to consider:
I zipped the dxf file (to help avoid data corruption when emailing) and then sent it to the Fabber for cutting.
Next: The Fabber takes over